G-protein–coupled receptors controlling pancreatic β-cell functional mass for the treatment of type 2 diabetes

The first phase of insulin secretion is altered during the early stages diabetes and followed by progressive loss ability glucose to stimulate secretion. primary causes secretory defects are still unknown. Better understanding signaling pathways linked activation G-protein–coupled receptors their mutual interactions in β-cells remains crucial. This represents a prerequisite for any strategy develop therapeutic tools that aim modulate function and/or mass β-cells. review summarizes knowledge over last two years on functionally expressed β-cells, which present key features development therapy type 2 diabetes.